Rapid 4D regional wall motion characterization of abdominal aortic aneurysms with intra-luminal thrombus using cine cardiac MRI

Background The clinical assessment of abdominal aortic aneurysm (AAA) rupture risk is largely limited to quantification of maximum diameter over time to monitor growth. Recent studies have extended this paradigm to modeling biomechanical loading and wall stresses using computational hemodynamics or solid mechanics simulations, in efforts to reliably numerically predict aneurysm-specific wall motion. However, the numerical simulation of aneurysm wall motion is time and resource intensive, and inherently involves complex mathematical modeling of often unrealistic wall properties. In this study, we characterize AAA wall motion using shape-analysis to quantify detailed regional function by direct processing of 4D (3D + time) cine CMR data.